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Published on: September 27, 2021
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Current Advances in Drug Delivery Systems for Capsule Endoscopy
Ivan Lyutakov1, Plamen Penchev1
1Department of Gastroenterology, University Hospital "Tsaritsa Yoanna-ISUL", Medical University Sofia, Sofia, Bulgaria.
Current Drug Metabolism
|July 20, 2020
Summary
Swallowable drug delivery systems for capsule endoscopy offer advanced gastrointestinal targeting. These innovations promise precise medication delivery, overcoming limitations of traditional oral methods for digestive diseases.
Area of Science:
- Gastroenterology and Biomedical Engineering
- Drug Delivery Systems
- Medical Device Innovation
Background:
- Traditional oral drug delivery systems have limitations in efficacy duration (12-24 hours) and are unsuitable for patients with short gastrointestinal transit times.
- Current modified-release formulations aim for once-daily dosing but cannot address rapid transit issues.
- Innovations in capsule endoscopy (CE) present a potential solution to overcome these limitations.
Purpose of the Study:
- To review recent advancements in drug delivery systems (DDS) specifically designed for capsule endoscopy (CE).
- To highlight the potential of CE-based DDS for precise drug targeting within the gastrointestinal tract.
- To explore the evolving landscape of therapeutic and diagnostic applications enabled by CE technology.
Main Methods:
- A narrative review of the MEDLINE database was conducted.
- Literature search spanned from 1991 to 2020.
- Keywords used included "drug delivery systems" and "capsule endoscopy," supplemented by hand searches and review of authoritative articles.
Main Results:
- Development of both microelectromechanical systems (MEMS) and non-mechanical patented technologies for CE-based DDS.
- Wireless capsule medical devices integrated with DDS offer novel diagnostic and therapeutic possibilities.
- Integration of CE, DDS, and cloud technology enables remote, real-time, automated, or responsive medication and treatment.
Conclusions:
- Swallowable drug delivery systems for capsule endoscopy represent a paradigm shift in managing digestive diseases.
- These systems offer novel diagnostic and therapeutic approaches.
- The technology paves the way for more personalized and effective gastrointestinal treatments.
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