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Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies
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Author Spotlight: Time and Cost-Effective Fibrinogen-PAGE for Fibrinogenolytic Studies

Published on: April 19, 2024

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Fibrinogen Diagnostics in Major Hemorrhage

Marek Bialkower1, Gil Garnier1

  • 1BioPRIA and Department of Chemical Engineering, Monash University, Clayton, Australia.

Critical Reviews in Analytical Chemistry
|July 21, 2020
PubMed

Fibrinogen is one of the first factors to fall to critically low levels in the blood in many coagulopathic events. Patients with hypofibrinogenemia are at a significantly greater risk of major hemorrhage and death. The rapid replacement of fibrinogen early on in hypofibrinogenemia may significantly improve outcomes for patients. Fibrinogen is present at concentrations between 2 and 4 g/L in the plasma of healthy people. However, hypofibrinogenemia is diagnosed when the fibrinogen level drops below 1.5-2 g/L. This review analyses different types of fibrinogen assays that can be used for diagnosing hypofibrinogenemia. The scientific mechanisms and limitations behind these tests are then presented. Additionally, the current state of clinical major hemorrhage protocols (MHPs) is presented and the structure, function and physiological role of fibrinogen is summarized.

Keywords:
Bloodcoagulopathyfibrinogen concentrationfibrinogen diagnosticmajor hemorrhagetransfusion

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