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Acute cardiac injury in patients with COVID-19

Andrea De Lorenzo1, Daniel Ab Kasal1, Bernardo R Tura1

  • 1Instituto Nacional de Cardiologia, Research and Teaching Department Rio de Janeiro, RJ, Brazil.

American Journal of Cardiovascular Disease
|July 21, 2020
PubMed

Insights

Myocardial injury, a serious cardiac complication of COVID-19, occurred in 16% of patients. Further research is vital to understand the full implications of this cardiac issue in COVID-19 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Cardiac complications associated with COVID-19 present significant life-threatening risks.
  • Myocardial injury in COVID-19 patients is a complex issue with multifactorial causes, attracting considerable research attention.

Purpose of the Study:

  • To systematically review and meta-analyze the existing literature on myocardial injury in COVID-19 patients.
  • To determine the frequency of myocardial injury in individuals diagnosed with COVID-19.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE and EMBASE databases.
  • Two independent reviewers assessed eligible studies for myocardial injury, defined by troponin elevation exceeding the 99th percentile.
  • Study heterogeneity and risk of bias were rigorously evaluated.

Main Results:

  • Eight studies, encompassing 1,229 patients, were included in the meta-analysis.
  • The pooled frequency of myocardial injury was found to be 16% (95% Confidence Interval: 9%-27%).
  • Significant heterogeneity was observed among the included studies, with an I² value of 93%.

Conclusions:

  • Myocardial injury is a recognized complication in COVID-19 patients, with a reported frequency of 16% based on current evidence.
  • Ongoing research is essential to continuously update findings as the COVID-19 pandemic evolves.
  • Further investigation is needed to fully elucidate the clinical implications of myocardial injury within the context of COVID-19 infection.
Abstract

Keywords:
COVID-19acute myocardial infarctionmyocardial injurymyocarditistroponin

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