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Construction a Long-Circulating Delivery System of Liposomal Curcumin by Coating Albumin
1Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P. R. China.
ACS Omega
|July 21, 2020
Summary
Coating liposomal curcumin with bovine serum albumin (BSA) creates a stable, long-circulating delivery system. This BSA-coated liposomal curcumin reduces macrophage uptake and slows drug release, enhancing its therapeutic potential.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Liposomal curcumin offers improved bioavailability and stability but suffers from short circulation times.
- Developing long-circulating drug delivery systems is crucial for enhancing therapeutic efficacy.
Purpose of the Study:
- To construct a long-circulating delivery system of liposomal curcumin by coating with bovine serum albumin (BSA).
- To investigate the physicochemical properties, drug release, and macrophage phagocytosis of BSA-coated liposomal curcumin (BSA-Cur-Lips).
Main Methods:
- Liposomal curcumin (Cur-Lips) was coated with BSA to form BSA-Cur-Lips.
- Physicochemical properties were analyzed using techniques including SDS-PAGE and XPS.
- In vitro drug release and macrophage phagocytosis assays were conducted using Raw264.7 cells.
Main Results:
- BSA-Cur-Lips exhibited enhanced sphericity, size homogeneity, and stability compared to Cur-Lips.
- Albumin coating prevented burst drug release and slowed curcumin release.
- Macrophage phagocytosis of liposomal curcumin was significantly reduced by BSA coating.
Conclusions:
- BSA coating is a promising strategy for developing long-circulating liposomal curcumin delivery systems.
- BSA-Cur-Lips demonstrate enhanced stability, controlled release, reduced phagocytosis, and potential for practical application.
