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Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

641
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
641

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Related Experiment Video

Updated: Dec 14, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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On-Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating.

Pingping Feng1, Zhenping Cao1, Xinyue Wang1

  • 1Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Advanced Materials (Deerfield Beach, Fla.)
|July 21, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanocoating to control bacterial bioagents. The coated bacteria remain inactive until reaching the intestine, where they reactivate for targeted therapy, improving treatment efficacy.

Keywords:
bacteriacoatingsgut microbiomeoral deliverytriggerable nanocoatings

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Area of Science:

  • Biotechnology
  • Microbiology
  • Materials Science

Background:

  • Bacteria are valuable bioagents for diagnosis and treatment due to their unique living characteristics.
  • Controlling bacterial activity precisely at the target site is crucial for efficacy and minimizing side effects.
  • Current methods for delivering bacteria face challenges in maintaining their activity and targeting specific locations.

Purpose of the Study:

  • To develop a strategy for on-demand bacterial reactivation using triggerable nanocoatings.
  • To enable bacteria to remain inactive during transit and activate only at the desired site of action.
  • To enhance the oral availability and therapeutic efficacy of bacterial bioagents.

Main Methods:

  • Bacteria were encapsulated within a pH-sensitive enteric nanocoating.
  • The nanocoating was designed to dissolve in the gastrointestinal environment, releasing active bacteria.
  • The efficacy of the coated bacteria was evaluated in mouse models of intestinal infection.

Main Results:

  • The enteric nanocoating protected bacteria from acidic environments during oral administration.
  • pH-triggered dissolution of the nanocoating in the intestine led to bacterial reactivation.
  • Improved oral bioavailability and enhanced treatment efficacy were observed in the tested mouse models.

Conclusions:

  • On-demand bacterial reactivation via triggerable nanocoatings offers a promising approach for precision bacterial therapy.
  • This strategy allows bacteria to be delivered safely and activate specifically at the target site.
  • The developed platform provides a robust method for creating advanced bacterial-mediated bioagents.