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Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Related Experiment Video

Updated: Jun 30, 2026

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.

Ying Wang^1,2, Zheng Zhu^1,2, Mian Chen²

¹College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.

Polymer Science & Technology (Washington, D.C.)

|June 29, 2026

Summary

This summary is machine-generated.

Polysaccharide encapsulation shields living microbes from physiological barriers and immune attack, enhancing their therapeutic potential. This strategy offers a versatile platform for developing advanced microbial therapeutics.

Keywords:

biomaterials microbial encapsulation polysaccharides probiotics synergistic therapy targeted delivery

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Last Updated: Jun 30, 2026

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Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

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Published on: March 30, 2020

Area of Science:

Biomaterials Science
Microbiology
Drug Delivery

Background:

Living microorganisms show therapeutic promise but face challenges like physiological barriers and immune system clearance.
Polysaccharide polymers offer innovative encapsulation strategies to overcome these limitations.

Purpose of the Study:

To review polysaccharide encapsulation strategies for enhancing living microbial therapeutics.
To analyze the functions and applications of polysaccharide-based encapsulation for microbial therapies.

Main Methods:

Review of encapsulation-compatible microbial taxa and polysaccharide properties (cationic, anionic, gel-forming, neutral).
Elaboration on non-covalent and covalent functionalization strategies for polysaccharides.
Analysis of key functions: protection, immunomodulation, targeted delivery, and synergistic therapy.

Main Results:

Polysaccharide encapsulation provides protective effects, immunomodulation, and targeted delivery for microbial therapeutics.
Applications demonstrated in treating tumors, bacterial infections, and inflammatory bowel diseases.

Conclusions:

Polysaccharide-based encapsulation is a versatile platform for augmenting the therapeutic functionality of living microbial therapeutics.
Further research is needed to address current challenges and guide the development of next-generation microbial therapeutics.