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Generating structurally and functionally programmable hydrogels by biological membrane hybridization.

Feng Wu1, Huan Chen2, Jinyao Liu3

  • 1State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

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|September 12, 2025
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Summary
This summary is machine-generated.

Researchers developed a novel biological membrane hybridization strategy to create programmable hydrogels for biomedical uses. This method enhances mechanical strength and allows tunable structure and function, overcoming limitations of current hydrogel technologies.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Hydrogels are promising for biomedical applications due to their flexibility and cargo capabilities.
  • Existing hydrogels face challenges in vivo, including weakened mechanical strength and uncontrolled release, hindering clinical translation.
  • Developing facile methods for hydrogels with adjustable structure and function remains a significant hurdle.

Purpose of the Study:

  • To introduce a versatile biological membrane hybridization strategy for creating structurally and functionally programmable hydrogels.
  • To demonstrate the fabrication of muscle-mimicking and skin-mimicking hydrogels using this novel approach.
  • To provide a robust platform for developing dual structure- and function-tunable hydrogels for diverse biomedical applications.

Main Methods:

  • Utilized biological membranes as cross-linkers within a supramolecular-covalent cascade reaction.
  • Constructed liposome-hybridized muscle-mimicking hydrogels and extracellular vesicle-hybridized skin-mimicking hydrogels.
  • Incorporated a second network to further tune hydrogel properties, expanding the strategy's applicability.

Main Results:

  • Developed muscle-mimicking hydrogels exhibiting swelling-strengthening mechanical behavior.
  • Fabricated skin-mimicking hydrogels with enhanced mechanical strength, lubricity, antibacterial, and immunoactivity.
  • Demonstrated the successful tuning of hydrogel structure and function through membrane hybridization and dual-network incorporation.

Conclusions:

  • The biological membrane hybridization strategy offers a facile and universal method for creating programmable hydrogels.
  • This approach successfully addresses limitations of conventional hydrogels, enabling enhanced performance for biomedical applications.
  • The developed platform provides a robust foundation for designing advanced biomimetic hydrogels with tailored properties.