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Updated: Dec 14, 2025

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Signatures of technetium oxidation states: a new approach
Stephen Bauters1, Andreas C Scheinost1, Katja Schmeide2
1The Rossendorf Beamline at ESRF - The European Synchrotron, CS40220, 38043 Grenoble Cedex 9, France. kristina.kvashnina@esrf.fr and Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Institute of Resource Ecology, Bautzner Landstr. 400, 01328 Dresden, Germany.
Abstract:
A general strategy for the determination of Tc oxidation state by new approach involving X-ray absorption near edge spectroscopy (XANES) at the Tc L3 edge is shown. A comprehensive series of 99Tc compounds, ranging from oxidation states I to VII, was measured and subsequently simulated within the framework of crystal-field multiplet theory. The observable trends in the absorption edge energy shift in combination with the spectral shape allow for a deeper understanding of complicated Tc coordination chemistry. This approach can be extended to numerous studies of Tc systems as this method is one of the most sensitive methods for accurate Tc oxidation state and ligand characterization.
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