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Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
Published on: July 2, 2018
[Experimental testing of the hydrogel dressing Geliperm]
J Staniszewska-Kuś1, D Paluch, L Solski
1Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Wrocławiu.
Abstract:
The dressing materials used in the local treatment for dressing large defects of skin, subcutaneous and muscular tissues do not have the optimum protective and therapeutic properties. We carry out experiments tending to achieve new kinds of dressing impermeable for microorganisms, free from toxic, allergic, action and acridity and not evoking pathological tissue reaction in a long-lasting contact with the wound. What is more, the new dressing should hasten the cicatrization process of a wound and enable its control as well as soothe the pain if it is possible. Some of these properties were achieved by the usage of cross-linked hydrophilic polymers with high ability of water absorption, creating elastic gels in its presence. The dressing of this type called Geliperm was produced by Geistlich Sons Ltd. and BYK Goldbin-Konstanz firms. The methods of evaluation of hydrogel dressing materials comprising a preliminary, standard and qualifying evaluation were worked out in the Department of Experimental Surgery and Biomaterials Research Medical Academy of Wrocław. According to the worked out scheme of experiments the Geliperm dressing was evaluated. We have discovered on the basis of the carried out experiments that the new generation of gel dressing has, to a large extent, the properties of the so called "ideal dressing".
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