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Elevated circulating Gpnmb levels are associated with hyperthyroidism.

Jiayang Lin1, Peizhen Zhang1, Yan Huang1

  • 1Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Endocrine Connections
|July 21, 2020
PubMed
Summary
This summary is machine-generated.

Circulating Glycoprotein non-metastatic protein B (Gpnmb) levels are higher in hyperthyroid patients and associated with disease risk. Gpnmb may serve as a biomarker for hyperthyroidism and its treatment monitoring.

Keywords:
Gpnmbhyperthyroidismmetabolismthyroid hormone

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Biomarker Discovery

Background:

  • Glycoprotein non-metastatic protein B (Gpnmb) is a hepatocyte-secreted cytokine involved in lipid homeostasis and metabolic health.
  • Its association with human hyperthyroidism remains unexplored.

Purpose of the Study:

  • To investigate the relationship between circulating Gpnmb levels and hyperthyroidism in humans.
  • To assess Gpnmb as a potential biomarker for hyperthyroidism risk and therapeutic response.

Main Methods:

  • Serum Gpnmb levels were measured in 180 hyperthyroid patients and 82 healthy controls.
  • Changes in Gpnmb were monitored in 46 hyperthyroid patients after 3 months of thionamide treatment.

Main Results:

  • Hyperthyroid patients exhibited significantly higher Gpnmb levels compared to controls (47.8 vs 31.0 ng/mL).
  • Gpnmb levels positively correlated with thyroid hormones (T3, T4) and basal metabolic rate (BMR).
  • Treatment reduced Gpnmb levels and improved thyroid function; Gpnmb was independently associated with hyperthyroidism risk (OR: 1.44).

Conclusions:

  • Circulating Gpnmb concentrations are independently associated with hyperthyroidism.
  • Gpnmb may serve as a valuable predictor of hyperthyroidism risk.
  • Gpnmb levels can be utilized for monitoring therapeutic effectiveness in hyperthyroid patients.