Cervical Artery Dissections with and without stroke, risk factors and prognosis: a Chilean prospective cohort

E Mazzon1, D Rocha2, A M Brunser1

  • 1Servicio de Neurología, Departmento de Neurología y Psiquiatría, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.

Insights

Spontaneous cervical artery dissection (CeAD) often occurs without stroke, showing a favorable prognosis. Men are more prone to stroke from CeAD, with earlier admission times being a key factor.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Cervical artery dissection (CeAD) is a significant cause of stroke in young adults.
  • Understanding risk factors for cerebrovascular complications in CeAD is crucial for patient management.

Purpose of the Study:

  • To characterize patients with spontaneous CeAD, comparing those with and without stroke.
  • To identify risk factors associated with cerebrovascular complications in a Chilean prospective cohort.

Main Methods:

  • A prospective cohort of consecutive CeAD patients confirmed by neuroimaging was analyzed.
  • Logistic regression models were employed to determine risk factors for stroke.

Main Results:

  • Of 168 CeAD patients, 29.2% experienced stroke. Men, internal carotid artery dissection, and vessel occlusion were associated with increased stroke risk.
  • Vertebral artery dissection and longer symptom onset to admission times were linked to decreased stroke risk.
  • Male sex and longer onset-to-admission time remained independent predictors of stroke after multivariate analysis.

Conclusions:

  • Spontaneous CeAD frequently presents as a non-stroke event with a generally favorable prognosis.
  • Despite higher CeAD incidence in women, stroke predominantly affects men, who tend to have earlier hospital admissions.

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