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Cervical Artery Dissections with and without stroke, risk factors and prognosis: a Chilean prospective cohort
E Mazzon1, D Rocha2, A M Brunser1
1Servicio de Neurología, Departmento de Neurología y Psiquiatría, Clínica Alemana de Santiago, Facultad de Medicina Clínica Alemana Universidad del Desarrollo, Santiago, Chile.
Insights
Spontaneous cervical artery dissection (CeAD) often occurs without stroke, showing a favorable prognosis. Men are more prone to stroke from CeAD, with earlier admission times being a key factor.
Area of Science:
- Neurology
- Vascular Medicine
- Epidemiology
Background:
- Cervical artery dissection (CeAD) is a significant cause of stroke in young adults.
- Understanding risk factors for cerebrovascular complications in CeAD is crucial for patient management.
Purpose of the Study:
- To characterize patients with spontaneous CeAD, comparing those with and without stroke.
- To identify risk factors associated with cerebrovascular complications in a Chilean prospective cohort.
Main Methods:
- A prospective cohort of consecutive CeAD patients confirmed by neuroimaging was analyzed.
- Logistic regression models were employed to determine risk factors for stroke.
Main Results:
- Of 168 CeAD patients, 29.2% experienced stroke. Men, internal carotid artery dissection, and vessel occlusion were associated with increased stroke risk.
- Vertebral artery dissection and longer symptom onset to admission times were linked to decreased stroke risk.
- Male sex and longer onset-to-admission time remained independent predictors of stroke after multivariate analysis.
Conclusions:
- Spontaneous CeAD frequently presents as a non-stroke event with a generally favorable prognosis.
- Despite higher CeAD incidence in women, stroke predominantly affects men, who tend to have earlier hospital admissions.
Abstract:
We aimed to characterize spontaneous cervical artery dissection (CeAD) patients with and without stroke and describe risk factors for cerebrovascular complications in a Chilean prospective cohort.
Methods:
Consecutive CeAD patients admitted to a Chilean center confirmed by neuroimaging. Logistic regression was used.
Results:
168 patients were included, median follow-up time was 157 days. Stroke occurred in 49 (29.2%) cases, 4 (2%) patients died, all of whom had a stroke, and 10 (6%) presented CeAD recurrence. In univariate analyses, men (odds ratio [OR] 3.97, 95% confidence interval [CI] 1.97-8.00, P < 0.001), internal carotid artery CeAD (OR 2.82, 95% CI 1.38-5.78, P = 0.005) and vessel occlusion (OR 4.45, 95% CI 1.38-14.38, P = 0.035) increased stroke risk. Conversely, vertebral artery dissection (OR 0.35, 95% CI 0.16-0.74, P = 0.006) and longer symptom onset to admission (O-A) time (OR 0.79, 95% CI 0.70-0.90, P < 0.001) were associated to decreased stroke risk. After multivariate analysis, men (OR 2.88, 95% CI 1.32-6.27, P = 0.008) and O-A time (OR 0.80, 95% CI 0.69-0.92, P = 0.002) remained independently associated with stroke.
Conclusion:
CeAD presented commonly as a non-stroke entity, with favorable prognosis. Albeit to a higher frequency of CeAD in women, stroke occurred predominantly in men, who were admitted earlier.
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