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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

184
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Thoracic Aorta01:15

Thoracic Aorta

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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

233
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

154
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
154
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

302
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Updated: Dec 14, 2025

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
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Thoracic aortic aneurysm gene dictionary.

Stefanie Rohde1, Mohammad A Zafar1, Bulat A Ziganshin1,2

  • 1Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA.

Asian Cardiovascular & Thoracic Annals
|July 22, 2020
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly impact thoracic aortic aneurysm and dissection risk. Understanding these genetic variants allows for personalized patient care and prediction of disease severity.

Keywords:
Aneurysmaortic aneurysmdissectinggenetic predisposition to diseasethoracic

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Area of Science:

  • Cardiovascular Genetics
  • Medical Genetics

Background:

  • Thoracic aortic aneurysm (TAA) is often asymptomatic until life-threatening rupture or dissection.
  • Genetic predisposition is a key factor in TAA and thoracic aortic dissection (TAD).
  • Familial cases exhibit more aggressive disease progression and earlier onset.

Purpose of the Study:

  • To highlight the role of genetic variations in TAA and TAD.
  • To emphasize the clinical utility of genetic profiling for personalized medicine.

Main Methods:

  • Review of genetic associations with syndromic and non-syndromic TAA/TAD.
  • Analysis of how specific gene variants influence disease phenotype.

Main Results:

  • Over 30 genes are linked to TAA and TAD.
  • Causative gene variants predict phenotype, including age of onset, dissection risk at smaller aortic diameters, and systemic manifestations.
  • A genetic "dictionary" enables personalized treatment strategies.

Conclusions:

  • Genetic sequencing is vital for expanding the understanding of TAA/TAD.
  • Personalized care based on genetic profiles is becoming a clinical reality for TAA/TAD patients.