Related Experiment Video
Updated: Dec 14, 2025

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic
Guo Yang1, Cheng Cheng2, Guo-Bo Xu2
1State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, School of Pharmacy, Guizhou Medical University, Guiyang 550004, China; The Second People's Hospital of Guizhou Province, Department of Pharmacy, Guiyang 550004, China.
Abstract:
The emergence of multidrug resistant microorganisms has triggered the impending need for new aitimicrobial strategies. The antivirulence strategy with the benefite of alleviating the drug resistance becomes the focus of research. In this study, 22 quorum sensing inhibitors were synthesized by mimicking the structure of autoinducer and acinetobactin and up to 34% biofilm inhibition was observed with 5u. The biofilm inhibition effect was further demonstrated with extracellular polysaccharides inhibition and synergism with Gentamycin sulphate.
More Related Videos
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Antimicrobial Effectiveness
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Hand hygiene
Hand washing...

