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Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas
Meiqing Li1, Ximing Shao2, Chunlei Wu2
1Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. hc.li@siat.ac.cn wu.su@siat.ac.cn lj.fang@siat.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
A convenient and efficient strategy was developed for accessing chlorotoxin-derived bicyclic peptide-biomolecule conjugates by cyclizing fully-unprotected linear peptides with a designed tetrafunctional chemical linker. Among these peptides, bicycle-P3 bearing the N-terminal sequence of chlorotoxin shows high tumor selectivity and penetration ability, which is promising for treatment of gliomas.
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