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ANCA-associated pauci-immune necrotizing glomerulonephritis during the treatment with pembrolizumab
Meral Uner1,2, Bassam Alhasson1, Jagdeep Obhrai3
1Renal Pathology Department, Faculty of Medicine, Medical School of Johns Hopkins University, Baltimore, MD, USA.
Abstract:
Cancer immunotherapy is rapidly changing the treatment paradigm in oncology, and immune checkpoint inhibitors (ICPIs) have been used successfully in a variety of cancer types. Specific side effects termed immune-related adverse events (irAEs) have now been described in various organ systems, including the kidney. Renal complications have rarely been reported compared with other irAEs and mostly consist of acute interstitial nephritis. Only rare cases of ICPI-related glomerulonephritis have been described. Herein, we report the case of an adult patient treated with pembrolizumab (anti-PD-1) for squamous cell carcinoma (SCC), who developed infectious enterocolitis, and ANCA-related with diffuse necrotizing crescentic glomerulonephritis, both conditions potentially linked to treatment with pembrolizumab.
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