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Cognitive impairment and depression after acute myocardial infarction: associations with ejection fraction and

Aleksandar Dikić1, Ljiljana Radmilo2, Željko Živanović3,4

  • 1Emergency Department, General Hospital, Dr Radivoj Simonović, Vojvođanska 75, 25 000, Sombor, Serbia. jelenasaric89@yahoo.com.

Acta Neurologica Belgica
|July 22, 2020
PubMed

Insights

Cognitive impairment after myocardial infarction is more common in older individuals. Depression is more prevalent in women following a heart attack. Ejection fraction levels did not significantly predict these outcomes.

Area of Science:

  • Cardiology
  • Neurology
  • Psychiatry

Background:

  • Cognitive impairment and depression frequently co-occur with acute myocardial infarction (AMI).
  • Risk factors for post-AMI cognitive impairment and depression remain incompletely understood.
  • Reduced ejection fraction is a known cardiac complication, but its specific link to cognitive and mood disorders post-AMI requires clarification.

Purpose of the Study:

  • To investigate the influence of reduced ejection fraction and demographic factors on cognitive impairment and depression after AMI.
  • To identify specific demographic predictors for cognitive decline and depressive symptoms in AMI survivors.
  • To analyze the relationship between ejection fraction, age, gender, and education with post-AMI cognitive and depressive outcomes.

Main Methods:

  • Prospective study involving 82 patients post-AMI.
  • Patients categorized by ejection fraction (<40% vs. ≥40%).
  • Cognitive function assessed using the Mini-Mental State Examination; depression evaluated with the Beck Depression Inventory.
  • Demographic data (age, gender, education) and comorbidities collected.

Main Results:

  • Ejection fraction level was not a significant predictor of cognitive impairment or depression post-AMI.
  • Patient age significantly predicted cognitive impairment (p=0.004), with a 1.16-fold increase in probability per year of life.
  • Female gender was a significant predictor of depression (p=0.014), with a 3.5-fold higher probability compared to males.
  • Cognitive impairment was more frequent in older patients; depression was more common in women.

Conclusions:

  • Age is a key demographic factor predicting cognitive impairment after AMI.
  • Female gender is a significant predictor of depression in patients recovering from AMI.
  • While ejection fraction is crucial for cardiac health, it does not appear to be a primary driver of cognitive impairment or depression in the AMI population studied.

Keywords:
Cognitive impairmentDepressionEjection fractionMyocardial infarction

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