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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
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Early developmental milestones in Duchenne muscular dystrophy
Paula van Dommelen1, Oisín van Dijk2, Jeroen A de Wilde2
1Department of Child Health, Netherlands Organisation for Applied Scientific Research TNO, Leiden, the Netherlands.
Developmental Medicine and Child Neurology
|July 22, 2020
Summary
Young males with Duchenne muscular dystrophy (DMD) show developmental delays in motor and non-motor milestones compared to controls. These delays appear early, aiding potential earlier diagnosis of DMD.
Area of Science:
- Pediatric Neurology
- Developmental Pediatrics
- Genetics
Background:
- Duchenne muscular dystrophy (DMD) is a genetic disorder affecting motor development.
- Early identification of developmental delays is crucial for timely intervention in pediatric conditions.
- Developmental milestones serve as key indicators of a child's progress.
Purpose of the Study:
- To compare the attainment of developmental milestones in young males with Duchenne muscular dystrophy (DMD) against a control group.
- To identify specific areas of developmental delay associated with DMD.
- To explore the potential of milestone attainment patterns for early DMD diagnosis.
Main Methods:
- A case-control study (4D-DMD) involving 76 young males with DMD and 12,414 controls.
- Data extracted from health care records on developmental milestones.
- Logistic regression analyses were used to compare milestone attainment between groups, adjusting for age.
Main Results:
- Young males with DMD exhibited delays in gross/fine motor, adaptive, personal/social, and communication milestones from 2-3 months of age.
- Age-adjusted odds ratios for delayed milestones ranged from 2.3 to 4.0 (p<0.01) initially.
- Differences in gross motor milestones significantly increased with age, with odds ratios up to 532 (p<0.001) between 12-36 months.
Conclusions:
- Significant delays in both motor and non-motor developmental milestones are present in young males with DMD.
- These delays are observable shortly after birth, suggesting early diagnostic potential.
- Monitoring specific developmental milestones could facilitate earlier detection and management of Duchenne muscular dystrophy.
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