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Synthetic Biology

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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Author Spotlight: Discovering New Biopesticides from Bioactive Soil Microbe-Derived Natural Products

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Building biosecurity for synthetic biology.

Benjamin D Trump¹, S E Galaitsi¹, Evan Appleton²

¹US Army Corps of Engineers, Engineer Research and Development Center, Vicksburg, MS, USA.

Molecular Systems Biology

|July 22, 2020

Summary

Synthetic biology advancements outpace current biosecurity measures. Proactive investment, early social scientist and policymaker engagement, and global coordination are crucial for future biosecurity.

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Area of Science:

Synthetic biology
Biosecurity
Global governance

Background:

Synthetic biology is rapidly evolving, posing challenges to existing biosecurity frameworks.
Current regulations are based on older paradigms like GMOs and recombinant DNA research.
Concerns exist that synthetic biology outpaces established biosafety and biosecurity measures.

Purpose of the Study:

To address the growing biosecurity concerns associated with synthetic biology.
To propose actionable strategies for enhancing biosecurity in the face of technological advancement.

Main Methods:

Commentary and analysis of current biosecurity strategies.
Review of scholarly discussions and practitioner concerns.
Proposal of future-oriented biosecurity strategies.

Main Results:

Existing biosecurity frameworks may be insufficient for synthetic biology.
Three key strategies are proposed to strengthen biosecurity.
The need for a paradigm shift in biosecurity approaches is highlighted.

Conclusions:

Biosecurity must be viewed as an investment in technological applicability.
Early integration of social scientists and policymakers is essential.
Global stakeholder coordination is necessary for effective risk management.