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Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity.
Amin Gasmi1, Pavan Kumar Mujawdiya2, Lyudmila Pivina3
1Societe Francophone de Nutritherapie et de Nutrigenetique Appliquee, Villeurbanne, France.
Current Medicinal Chemistry
|July 23, 2020
Summary
Increased intestinal permeability and gut dysbiosis contribute to obesity and low-grade inflammation. This review explores how these gut health issues, including the microbiota-gut-brain axis, drive metabolic disorders.
Area of Science:
- Metabolic Science
- Microbiology
- Gastroenterology
Background:
- Intestinal hyperpermeability is a metabolic process linked to gut microbiota composition.
- Gut dysbiosis and increased intestinal permeability are associated with obesity and low-grade inflammation.
- These conditions elevate pro-inflammatory cytokine levels and can exacerbate inflammatory bowel syndrome.
Purpose of the Study:
- To elucidate the mechanisms connecting intestinal hyperpermeability, gut microbiota, and obesity.
- To review the role of gut dysbiosis in metabolic dysregulation.
- To discuss the impact on the microbiota-gut-brain axis.
Main Methods:
- Literature review of studies on intestinal hyperpermeability, gut microbiota, and obesity.
- Analysis of pathways linking gut barrier function to metabolic health.
- Examination of the role of inflammation and endotoxemia.
Main Results:
- Gut microbiota imbalance is implicated in metabolic regulation and diseases like obesity.
- Combined intestinal hyperpermeability and dysbiosis increase inflammation in obese individuals.
- Impaired intestinal barrier integrity contributes to metabolic disorders via endotoxemia.
Conclusions:
- Intestinal hyperpermeability and gut dysbiosis are key factors in obesity development.
- Alterations in the gut microbiota-gut-brain axis are associated with metabolic disorders.
- Understanding these gut-related mechanisms is crucial for metabolic health research.
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