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Factors Associated With Asthma Control in 121 Preschool Children
P Leiria-Pinto1,2, P Carreiro-Martins1,2, I Peralta1
1Immunoallergology Department, Hospital Dona Estefânia - CHULC, EPE, Lisbon, Portugal.
Summary
Asthma flare-ups, rhinitis, and lung function changes predict uncontrolled asthma in preschoolers. These findings help identify children needing closer asthma management and monitoring.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Asthma Research
Background:
- Asthma control in preschool children is poorly understood.
- Risk factors for uncontrolled asthma in this age group require clarification.
Purpose of the Study:
- To investigate associations between clinical/functional parameters and uncontrolled asthma in preschoolers.
- To identify predictors of poor asthma control in young children.
Main Methods:
- Recruited preschool children (3-5 years) with asthma and healthy controls.
- Utilized questionnaires for risk factors and Global INitiative for Asthma criteria for control.
- Assessed lung function and bronchial reversibility via impulse oscillometry and spirometry.
Main Results:
- 50% of children with asthma had uncontrolled disease.
- Increased risk factors included >3 flare-ups, moderate-to-severe rhinitis, and lung function variability (FVC, FEV1).
- Models incorporating lung function variability showed high discriminative ability (AUC 0.81-0.82).
Conclusions:
- Clinical and functional parameters are linked to uncontrolled asthma in preschoolers.
- Further research is warranted to validate impulse oscillometry's role in asthma management.
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