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The relationship between the severity of coronary artery disease and skin measurement parameters
Eda Öksüm Solak1, Gözde Emel Gökçek2, Demet Kartal1
1Dermatology and Venereology Department, Erciyes University Medical School, Kayseri, Turkey.
Insights
Skin sebum and transepidermal water loss (TEWL) measurements show potential as inexpensive, noninvasive predictors for coronary artery disease (CAD). These skin parameters may aid in early detection and risk assessment for cardiovascular conditions.
Area of Science:
- Dermatology
- Cardiology
- Biomedical Engineering
Background:
- Coronary artery disease (CAD) poses a significant global health burden.
- Noninvasive biomarkers for early CAD detection are highly sought after.
- Skin characteristics may reflect systemic physiological changes associated with CAD.
Purpose of the Study:
- To explore the association between specific skin parameters and the presence of CAD.
- To evaluate the potential of noninvasive skin measurements as predictive markers for CAD.
- To compare skin parameter values between CAD patients and a healthy control group.
Main Methods:
- Recruited 50 patients with diagnosed CAD and 45 healthy controls.
- Measured skin transepidermal water loss (TEWL), pH, temperature, electrical capacitance, sebum, and elasticity.
- Utilized noninvasive techniques on the forehead, back, and forearm.
Main Results:
- CAD patients exhibited significantly higher skin temperature on the back and forehead.
- Significantly higher TEWL was observed in CAD patients across all measured regions.
- Skin elasticity (R2 and R6) was significantly altered in CAD patients.
- No significant difference in sebum levels between groups on the back and forehead, but higher in the forearm for patients.
Conclusions:
- Skin sebum and TEWL measurements show promise as cost-effective, noninvasive tools for CAD prediction.
- These noninvasive skin parameters may serve as valuable indicators in cardiovascular risk assessment.
- Further research is warranted to validate these findings and integrate them into clinical practice.
Purpose:
This study aimed to investigate the relationship between skin parameters and CAD.
Materials And Methods:
The study included 50 patients diagnosed with coronary artery disease as the patient group and 45 volunteers without any known coronary artery disease as the control group. The participants' skin TEWL, pH, temperature, electrical capacitance, sebum, and elasticity values were measured using noninvasive methods at the forehead, back, and forearm.
Findings:
Skin temperature was significantly higher in the back and forehead regions in the patient group. No difference was found between the sebum values of the patient and control groups at the back and forehead. A significantly higher result was obtained for the forearm area. The pH was significantly lower in the patients' forearm, although the obtained values were within the normal range. The TEWL was significantly higher in patients in all three regions. In terms of flexibility, R2 was significantly higher in the back and forehead regions of the patient group, and the R6 was significantly higher in the patient group in all three regions. In addition, there was no correlation between skin parameter and SYNTAX score increase measurements.
Conclusion:
It can be suggested that skin sebum and TEWL measurements can be accepted as cheap and noninvasive methods of predicting CAD.
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