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Updated: Dec 14, 2025

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Published on: May 29, 2021
Control by one drop of solvent: selective preparation of guest release/trap-triggered interconvertible molecular
Yumi Yakiyama1, Takahisa Fujinaka, Mio Nishimura
12-1 Yamadaoka, Suita, Osaka 565-0871, Japan. yakiyama@chem.eng.osaka-u.ac.jp.
Abstract:
Interconvertible molecular crystals 1close and 1open composed of 4-pyridyl-1,3-indanedione dimer 1 were selectively obtained. Thermal removal of solvent molecules in 1open afforded 1close. Further dipping of 1close in a specific solvent reproduced 1open. No crystallinity loss was observed even though both processes involved a drastic change of molecular packing arrangements.
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