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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Related Experiment Video

Updated: Dec 14, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Long non-coding RNA H19 in atherosclerosis: what role?

Xian Shi1, Ya-Ting Wei1, Heng Li2

  • 1School of Medicine, Guilin Medical University, Guilin, 541100, Guangxi, China.

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|July 24, 2020
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Long non-coding RNAs (lncRNAs), like H19, are key regulators in atherosclerosis. This review explores lncRNA-H19

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Area of Science:

  • Molecular Biology
  • Cardiovascular Research
  • Genetics

Background:

  • Atherosclerosis (AS) is a complex, multistep disease involving angiogenesis and inflammation.
  • Long non-coding RNAs (lncRNAs) are critical regulators of gene expression.
  • lncRNA-H19 is implicated in various cellular processes relevant to AS.

Purpose of the Study:

  • To review the role of lncRNA-H19 in atherosclerosis-related pathophysiological processes.
  • To elucidate the mechanisms by which lncRNA-H19 influences atherosclerosis development.
  • To enhance understanding of lncRNA-H19's biological functions in AS.

Main Methods:

  • Literature review of studies on lncRNA-H19 and atherosclerosis.
  • Analysis of lncRNA-H19's regulatory functions in angiogenesis, inflammation, lipid metabolism, and cell processes.
  • Synthesis of current knowledge on lncRNA-H19's involvement in AS pathogenesis.

Main Results:

  • lncRNA-H19 significantly impacts angiogenesis, inflammatory responses, and lipid metabolism in AS.
  • It regulates cellular proliferation and apoptosis, crucial for atherosclerotic plaque development.
  • Evidence suggests lncRNA-H19 acts as a key modulator in multiple AS-related pathways.

Conclusions:

  • lncRNA-H19 is a critical factor in the pathogenesis of atherosclerosis.
  • Understanding lncRNA-H19 mechanisms offers potential therapeutic targets for AS.
  • Further research into lncRNA-H19 functions is vital for cardiovascular disease management.