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Updated: Dec 14, 2025

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
Oxidative stress in etiopathogenesis of inflammatory bowel diseases
Michal Kloska1, Dorota Mańkowska-Wierzbicka2, Magdalena Człapka-Matyasik3
1Department of Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania, USA. michalkloska@gmail.com.
Abstract:
Inflammatory bowel diseases are a group of chronic diseases of the digestive tract of unknown origin. The etiology of IBD is multifactorial and involves interaction between genetic, environmental and immunological factors with oxidative stress being an inherent part of any one of them. Therefore, the redox equilibrium is crucial to maintain cell homeostasis in the gastrointestinal (GI) tract, which is constantly exposed to large numbers of commensal and pathological bacteria. Distortion of this homeostasis and increase in oxidative stress leads to the propagation of inflammation, mucosal injury in the GI tract and is associated with the development and exacerbation of IBD.
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