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High serum uric acid is associated with increased arterial stiffness in hypertension

Li-Na An1,2, Ning Rong3, Min Ning1

  • 1Department of Geriatrics, Shanghai First People's Hospital Affiliated to Nanjing Medical University, Shanghai 200080, China.

Aging
|July 24, 2020
PubMed

Insights

High serum uric acid levels are a significant risk factor for arterial stiffness in Chinese adults with hypertension. This finding highlights the importance of monitoring uric acid for cardiovascular health in this population.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Hypertension Research

Background:

  • Serum uric acid levels are linked to cerebrovascular diseases.
  • The role of serum uric acid as a risk factor for arterial stiffness in hypertensive individuals remains unclear.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and arterial stiffness.
  • To determine if serum uric acid is a risk factor for arterial stiffness in a hypertension population.

Main Methods:

  • A cohort of 10,450 participants with hypertension was analyzed.
  • Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV).
  • Multivariate-adjusted linear and logistic regression analyses were employed.

Main Results:

  • Significant differences in high baPWV were observed across serum uric acid quartiles in both females and males (p<0.01).
  • Elevated serum uric acid levels were associated with increased odds of high baPWV in a dose-dependent manner, even after adjusting for confounders.
  • Odds ratios for the highest baPWV quartile increased with higher serum uric acid levels in both sexes.

Conclusions:

  • Serum uric acid level is an important risk factor for arterial stiffness.
  • Findings are particularly relevant for the Chinese hypertension population.
  • Monitoring serum uric acid may aid in assessing cardiovascular risk in hypertensive patients.

Keywords:
arterial stiffnesshypertensionmultivariate analysispulse wave velocityserum uric acid

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