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Orthotopic Left Lung Transplantation in Rats
Published on: July 3, 2025
483
Advances in lung transplantation for interstitial lung diseases
Laurens J De Sadeleer1,2, Stijn E Verleden1, Robin Vos1,2
1Department of CHROMETA, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE).
Current Opinion in Pulmonary Medicine
|July 24, 2020
Summary
Lung transplantation (LTx) offers curative intent for interstitial lung diseases (ILDs). Optimizing pre-LTx care, including antifibrotic use and patient management, improves survival outcomes for ILD patients undergoing LTx.
Area of Science:
- Pulmonology
- Transplant Surgery
- Medical Research
Background:
- Lung transplantation (LTx) is a critical treatment for end-stage interstitial lung diseases (ILDs).
- Recent advancements focus on improving outcomes for ILD patients undergoing LTx.
Purpose of the Study:
- To review recent findings and evolutions in lung transplantation for interstitial lung diseases.
- To provide an overview of current best practices in pre-LTx management for ILD patients.
Main Methods:
- Literature review of studies published within the last two years.
- Analysis of data on LTx outcomes in specific ILD entities.
- Evaluation of pre-LTx management strategies, including antifibrotic treatment.
Main Results:
- Adequate LTx outcomes are reported across various ILD types, though telomeropathies can impact survival.
- Single vs. double LTx outcomes are comparable; both remain acceptable options.
- Optimizing pre-LTx management (avoiding corticosteroids, using antifibrotics, managing BMI/nutrition, implementing rehabilitation and depression screening) significantly improves post-LTx survival.
Conclusions:
- Lung transplantation is the only curative option for ILDs, with evolving strategies enhancing patient survival.
- Pre-transplant optimization by ILD specialists is crucial for successful LTx outcomes.
- Individualized pre-LTx management plans are key to maximizing survival benefits for ILD patients.
