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Updated: Dec 14, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Incidental Detection of Malignant Melanoma Brain Recurrence on 68Ga-Prostate-Specific Membrane Antigen PET/CT
Nir Hod1, Sophie Lantsberg1, Elya Benkovich2
1From the Institute of Nuclear Medicine and Molecular Imaging.
Abstract:
A 76-year-old man with a prior medical history of resected malignant melanoma of the skull underwent Ga-prostate-specific membrane antigen (PSMA) PET/CT due to rising tumor markers of a known prostate carcinoma. Unexpected high Ga-PSMA brain uptake was encountered around the surgical cavity in the skull with initially no specific structural changes on anatomical imaging. Successive CT and MRI eventually revealed local melanoma brain recurrence at this site. This interesting case demonstrates the diagnostic potential of Ga-PSMA PET/CT imaging for detection of malignant melanoma brain recurrence.

