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Whole-Body Nanoparticle Aerosol Inhalation Exposures

Whole-Body Nanoparticle Aerosol Inhalation Exposures

Published on: May 7, 2013

Inhaled nanoparticles-An updated review.

Tuangrat Praphawatvet¹, Jay I Peters², Robert O Williams¹

¹Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, United States.

International Journal of Pharmaceutics

|July 24, 2020

Summary

This review updates knowledge on inhaled nanoparticles, highlighting their potential for improved drug delivery and therapeutic efficacy in the lungs. Nanomaterials offer promise for health advancements, but their public health impact requires further study.

Keywords:

Drug delivery Nanoparticles Nanotechnology Nanotoxicology Poorly water-soluble drug Protein/peptide drug Pulmonary delivery

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Area of Science:

Nanotechnology
Pulmonary Drug Delivery
Environmental Health

Background:

Nanotechnology offers potential health and manufacturing advancements.
Current knowledge on nanomaterials' public health impact is limited.
The lungs serve as an ideal target for non-invasive drug delivery.

Purpose of the Study:

To review recent literature on inhaled nanoparticles.
To discuss nanomaterial properties, disposition, and influencing factors.
To explore pulmonary drug delivery applications and updated technologies.

Main Methods:

Literature review of recent reports on inhaled nanoparticles.
Analysis of nanomaterial properties and their fate after inhalation.
Examination of environmental epidemiology and toxicology data.

Main Results:

Inhaled nanoparticles show potential for improved therapeutic efficacy and reduced side effects.
Pulmonary delivery via nanoparticles is effective for specific drug types.
Updated delivery systems and process technologies are presented.

Conclusions:

Inhaled nanoparticles represent a promising frontier for local and systemic therapies.
Further research is needed to fully understand the public health implications of nanomaterials.
Nanotechnology holds significant promise for advancing patient care and manufacturing.