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An Eltrombopag Red (Plasma) Alert.

Hanny Al-Samkari1, Katayoon Goodarzi2

  • 1Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA, hal-samkari@mgh.harvard.edu.

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|July 24, 2020
PubMed
Summary
This summary is machine-generated.

Eltrombopag, used for aplastic anemia, can cause reddish-brown plasma. This side effect may mimic hemolysis and interfere with lab tests, leading to false alarms.

Keywords:
Aplastic anemiaBrownEltrombopagPlasmaRed

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Area of Science:

  • Hematology
  • Pharmacology

Background:

  • Eltrombopag is a thrombopoietin receptor agonist.
  • It is commonly used for immune thrombocytopenia and aplastic anemia.

Observation:

  • High-dose eltrombopag for aplastic anemia, unlike lower doses for immune thrombocytopenia, can cause plasma discoloration.
  • This reddish-brown plasma can mimic hemolysis or rhabdomyolysis.

Findings:

  • The patient presented with reddish-brown plasma, initially raising concerns for hemolysis or rhabdomyolysis.
  • This discoloration is a known, albeit infrequent, side effect of high-dose eltrombopag therapy.

Implications:

  • Clinicians should be aware of eltrombopag-induced plasma discoloration.
  • This awareness can prevent misdiagnosis and unnecessary investigations for hemolysis or rhabdomyolysis.