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Immune-Mediated Neuropathies.

Kelly G Gwathmey1, A Gordon Smith1

  • 1Department of Neurology, Virginia Commonwealth University, 1101 East Marshall Street, PO Box 980599, Richmond, VA 23298-0599, USA.

Neurologic Clinics
|July 25, 2020
PubMed
Summary
This summary is machine-generated.

This article reviews immune-mediated neuropathies, including Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. Early diagnosis and treatment of these nerve disorders are crucial to prevent long-term disability.

Keywords:
Autoimmune neuropathyCIDPGuillain-Barré syndromeMiller-Fisher syndromeMultifocal motor neuropathyNodo-paranodopathySensory neuronopathyVasculitic neuropathy

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Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Immune-mediated neuropathies encompass a diverse group of disorders affecting the nervous system.
  • These conditions are characterized by inflammation and damage to nerve fibers, leading to varying clinical presentations.

Observation:

  • The article covers common inflammatory demyelinating polyradiculoneuropathies like Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.
  • Rarer variants, including Miller-Fisher syndrome, multifocal motor neuropathy, vasculitic neuropathies, and sensory neuronopathies (dorsal root ganglionopathies), are also discussed.

Findings:

  • Case studies highlight the distinct clinical patterns of these immune-mediated neuropathies.
  • Diagnostic evaluation and treatment strategies are provided for each condition.

Implications:

  • Prompt identification of immune-mediated neuropathies is essential for effective management.
  • Timely intervention can mitigate prolonged morbidity and prevent permanent neurological disability.