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Updated: Dec 14, 2025
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Fluid Overload and Acute Kidney Injury
Vijaya P Patil1, Bindiya G Salunke1
1Division of Clinical Anaesthesiology, Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Parel, Mumbai, Maharashtra, India.
Summary
Fluid therapy is crucial for hospitalized patients but can be harmful. Both too little and too much fluid can cause organ injury, including acute kidney injury (AKI).
Area of Science:
- Critical care medicine
- Nephrology
Background:
- Fluid therapy is a common intervention for hospitalized and critically ill patients.
- It is primarily used for hemodynamic stability and to prevent or manage acute kidney injury (AKI).
Purpose of the Study:
- To highlight the dual nature of fluid administration in critical care.
- To discuss the risks of both fluid inadequacy and fluid overload.
Main Methods:
- This is a review/discussion of existing knowledge and clinical practice regarding fluid therapy.
- It synthesizes information on the indications, benefits, and risks of fluid administration.
Main Results:
- Fluid administration is essential but carries risks.
- Inadequate fluid resuscitation can lead to hypoperfusion and organ injury.
- Excessive fluid administration (fluid overload) can also cause adverse outcomes, including AKI.
Conclusions:
- Fluid therapy requires careful balance to avoid detrimental effects.
- Hypervolemia, despite being a potential consequence of fluid administration, can paradoxically cause AKI.
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