Related Experiment Video
Updated: Dec 14, 2025
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
Gut microbiota metabolites as integral mediators in cardiovascular diseases (Review)
Ying Zhu1, Xiaorong Shui2, Zheng Liang3
1Laboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China.
Insights
Cardiovascular diseases (CVDs) are linked to gut microbiota imbalances. Analyzing gut microbiota metabolites offers insights into CVD development and potential treatments with minimal side effects.
Area of Science:
- Microbiology
- Cardiology
- Metabolomics
Background:
- Cardiovascular diseases (CVDs) contribute significantly to global morbidity and mortality.
- CVDs are increasingly associated with gut microbiota dysbiosis and altered metabolite profiles.
- Gut microbiota metabolites, including trimethylamine N-oxide and short-chain fatty acids, play a role in CVD pathogenesis.
Purpose of the Study:
- To analyze the impact of gut microbiota metabolites on cardiovascular disease (CVD) occurrence and progression.
- To identify effective and safe therapeutic strategies for CVDs targeting the gut microbiota.
Main Methods:
- Review of existing research on gut microbiota and CVDs.
- Analysis of key microbial metabolites and their associated cellular pathways.
- Evaluation of interventions like probiotics and exercise for modulating gut microbiota composition.
Main Results:
- Gut microbiota imbalance is a common feature in patients with CVDs.
- Specific metabolites produced by gut bacteria can either promote or protect against CVD development.
- Modulating gut flora through diet, probiotics, or exercise may offer therapeutic benefits for CVDs.
Conclusions:
- Gut microbiota metabolites are crucial in CVD pathogenesis and represent potential therapeutic targets.
- Interventions aimed at restoring gut microbiota balance show promise for CVD prevention and treatment.
- Further research into cost-effective, minimally invasive microbiota-targeted therapies is warranted.
Abstract:
Cardiovascular diseases (CVDs), such as atherosclerosis, hypertension, myocardial infarction and diabetic heart disease, are associated with high morbidity and mortality rates worldwide, and may also induce multiple organ failure in their later stages, greatly reducing the long‑term survival of the patients. There are several causes of CVDs, but after nearly a decade of investigation, researchers have found that CVDs are usually accompanied by an imbalance of gut microbiota and a decreased abundance of flora. More importantly, the metabolites produced by intestinal flora, such as trimethylamine and trimethylamine N‑oxide, bile acids, short‑chain fatty acids and aromatic amino acids, exert different effects on the occurrence and development of CVDs, as observed in the relevant pathways in the cells, which may either promote or protect against CVD occurrence. It is known that changes in the intestinal flora following antibiotic administration, diet supplementation with probiotics, or exercise, can interfere with the composition of the intestinal flora and may represent an effective approach to preventing or treating CVDs. The focus of this review was the analysis of gut microbiota metabolites to elucidate their effects on CVDs and to identify the most cost‑effective and beneficial methods for treating CVDs with minimal side effects.
More Related Videos
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:30Coronary Artery Disease I: Introduction
01:27Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
01:29Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...