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Laryngeal granular cell tumors in children: A literature review
Taha A Mur1, William R Pellegrini2, Lauren F Tracy3
1Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, MA, USA.
Insights
Pediatric laryngeal granular cell tumors are rare, often presenting as dysphonia. Most occur in the subglottis, with posterior locations more common. Long-term surveillance for recurrence is advised.
Area of Science:
- Pediatric Otolaryngology
- Pediatric Oncology
- Head and Neck Surgery
Background:
- Granular cell tumors (GCTs) are rare in children, particularly in the larynx.
- Understanding their characteristics and management in pediatric patients is crucial.
Purpose of the Study:
- To characterize features of pediatric laryngeal granular cell tumors.
- To review management trends and outcomes for these rare tumors.
Main Methods:
- Systematic literature search of PubMed, Ovid Medline, and Cochrane Collaboration databases.
- Inclusion criteria focused on pediatric patients diagnosed with laryngeal granular cell tumors.
Main Results:
- 38 pediatric cases identified (ages 4-16 years); dysphonia was the most common symptom.
- Subglottic (49%) and glottic (43%) tumors were most frequent, with posterior locations more common (53%).
- Recurrence occurred in 4 patients; management included excision, laser, laryngofissure, and laryngectomy.
Conclusions:
- Pediatric laryngeal granular cell tumors predominantly affect the subglottis, often posteriorly.
- Multifocal disease should be assessed, and long-term surveillance for recurrence is recommended.
Objective:
Granular cell tumors of the larynx are exceedingly rare in the pediatric population. The purpose of this review is to further characterize features of these tumors and trends in their management.
Methods:
A search of the PubMed, Ovid Medline and Cochrane Collaboration databases was undertaken using the terms: pediatric, child, laryngeal, larynx, granular cell tumor, granular cell myoblastoma, benign mass.
Results:
A total of 38 children with laryngeal granular cell tumor were identified. Their ages ranged from 4 to 16 years. The most common presenting symptom was dysphonia. Five patients were previously treated for asthma. Within the laryngeal subsites, 49% presented with subglottic tumors, while 43% were found at the level of the glottis. Subglottic tumors were found anteriorly 42% of the time and posteriorly 53% of the time. Multifocal disease was present in four patients. Around half of patients were treated by cold steel excision and/or CO2 laser, 31% through laryngofissure, and two required laryngectomy. There were four documented cases of recurrence ranging from 4 months to 3 years after treatment.
Conclusions:
Laryngeal granular cell tumor during childhood occurs most commonly in the subglottis. Posterior laryngeal tumors were more frequent than anterior tumors. Patients should be carefully evaluated for multifocal disease. Long-term surveillance for recurrence is recommended.
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