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Updated: Dec 13, 2025
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and
Prateek Ranjan Yadav1,2, Tao Han1, Ololade Olatunji3
1Chemical Engineering Department, Loughborough University, Loughborough LE11 3TU, Leicestershire, UK.
Pharmaceutics
|July 26, 2020
Summary
Microneedles (MNs) offer painless transdermal drug delivery (TDD) with minimal skin damage. This review highlights the importance of modeling and simulation for optimizing MN performance in drug delivery systems.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmaceutical Sciences
Background:
- Microneedles (MNs) have gained significant attention for painless transdermal drug delivery (TDD).
- Various materials and fabrication methods yield MN arrays with diverse properties influencing drug release.
- MN performance is critically dependent on their dimensions, shape, and geometry.
Purpose of the Study:
- To review the current state of microneedle modeling research for drug delivery.
- To emphasize the role of mathematical modeling, simulation, and optimization in enhancing MN performance.
- To discuss the theoretical underpinnings of MN-enhanced diffusion for TDD.
Main Methods:
- Literature review of microneedle modeling research.
- Discussion of theoretical frameworks for simulating MN-enhanced diffusion.
- Analysis of factors influencing drug release profiles from MNs.
Main Results:
- Mathematical models are crucial for predicting in vivo MN performance, incorporating skin properties.
- Modeling can significantly reduce time and cost in MN studies and manufacturing.
- Recent models effectively predict MN performance by considering skin's structural and mechanical characteristics.
Conclusions:
- Modeling, simulation, and optimization are vital for achieving desired microneedle drug delivery performance.
- A better understanding of MN-mediated drug delivery processes is facilitated by theoretical modeling.
- This review provides insights into the modeling of microneedle-based transdermal drug delivery systems.
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