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Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Related Experiment Video

Updated: Dec 13, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

Microbial involvement in Alzheimer disease development and progression.

Hannah R Bulgart¹, Evan W Neczypor^2,3, Loren E Wold^2,3,4

¹Biomedical Sciences Graduate Program, College of Medicine, The Ohio State University, Columbus, OH, USA.

Molecular Neurodegeneration

|July 26, 2020

Summary

Recent studies suggest resident bacteria may drive Alzheimer disease (AD) progression. This review explores microbial links to neuroinflammation and amyloid plaque formation in AD.

Keywords:

Alzheimer disease Gut microbiota Oral microbiota

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Last Updated: Dec 13, 2025

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Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

Area of Science:

Neuroscience
Microbiology
Pathology

Background:

Alzheimer disease (AD) is a leading cause of death in older adults, characterized by senile plaques, neurofibrillary tangles, and neuroinflammation.
The precise mechanisms driving AD pathogenesis, including the role of neuroinflammation, remain incompletely understood.

Purpose of the Study:

To review recent research investigating the potential role of resident microbial populations in the development and progression of Alzheimer disease.
To explore how microbes might contribute to key AD pathologies like neuroinflammation and senile plaque formation.

Main Methods:

Literature review of recent studies on microbial involvement in Alzheimer disease.
Analysis of research linking resident bacteria to neuroinflammation and AD pathology.

Main Results:

Emerging evidence suggests a hypothesis where resident bacteria contribute to AD pathogenesis.
Microbial involvement may be linked to increased neuroinflammation, senile plaque accumulation, and potentially neurofibrillary tangles.

Conclusions:

The role of resident microbial communities in Alzheimer disease requires further investigation.
Understanding microbial contributions could offer novel therapeutic targets for AD.