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Published on: November 4, 2010
Zataria multiflora induced bronchodilatoion comparable to theophylline syrup in asthmatic patients
Mostafa Boskabady1, Azam Alavinezhad1, Mohammad Hossein Boskabady2
1Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Objective:
The bronchodilatory effect of hydro-ethanolic extract of Z. multiflora was examined in asthmatic patients.
Design:
Pulmonary function tests (PFTs) were measured before and 15, 30, 60, 90, 120, 150, and 180 min after administration of the extract (20 mg/kg) in 18 asthmatics and after theophylline syrup (6 mg/kg) in 12 patients.
Main Outcome Measures:
The extract of Z. multiflora significantly increased all PFT values, 30 to 180 min post-administration similar to the effect of theophylline (all, p<0.001). Increased PFT values due to the extract were significantly declined 180 min but the effects of theophylline were declined 150 min after administration (p<0.05 to p<0.001). Values of PFTs at baseline, 30 and 180 min after drugs administration were not singnificantly different between the extract and theophylline.
Conclusions:
Z. multiflora showed a bronchodilatory effect in asthmatic patients comparable to theophylline effect but with a longer duration of action.
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