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Updated: Dec 13, 2025

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
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Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer

Zheng Zhou1, Bao Sun2,3, Shiqiong Huang4

  • 1Department of Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

Cell Death & Disease
|July 26, 2020
PubMed

Insights

Aminoacyl-tRNA synthetases (ARSs) and their interacting proteins (AIMPs) are crucial for cellular homeostasis. This review explores their roles in cancer, highlighting potential therapeutic strategies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis.
  • ARS-interacting multi-functional proteins (AIMPs) form a complex (MSC) involved in cellular homeostasis.
  • AIMPs, though non-enzymatic, are increasingly recognized for tumor-suppressive functions.

Purpose of the Study:

  • To review the biological functions of AIMP1, EMAP II, AIMP2, AIMP2-DX2, and AIMP3.
  • To systematically introduce the emerging roles of these proteins in cancer.
  • To offer novel insights for cancer treatment strategies.

Main Methods:

  • Literature review of existing research on ARSs and AIMPs.
  • Analysis of functional roles and cancer-related activities.
  • Synthesis of information on AIMP1, EMAP II, AIMP2, AIMP2-DX2, and AIMP3.

Main Results:

  • AIMPs play a scaffolding role in the MSC and exhibit tumor-suppressive activities.
  • EMAP II (AIMP1 cleavage product) and AIMP2-DX2 (AIMP2 splice variant) are implicated in tumorigenesis.
  • The reviewed proteins demonstrate diverse biological functions with significant implications in cancer.

Conclusions:

  • AIMP family proteins and their derivatives have critical roles in cancer development and progression.
  • Understanding these roles can lead to the development of new cancer therapies.
  • Further research into ARS-MSC components offers promising avenues for oncology.

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