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Updated: Dec 13, 2025
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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Crosstalk between COVID-19 and prostate cancer
Hisham F Bahmad1,2, Wassim Abou-Kheir3
1Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Prostate Cancer and Prostatic Diseases
|July 26, 2020
Summary
Prostate cancer treatments, like androgen-deprivation therapies (ADT), may offer protection against COVID-19. Further research is needed to explore if these therapies can be repurposed for treating COVID-19 patients.
Area of Science:
- Virology
- Oncology
- Pharmacology
Background:
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a global pandemic (COVID-19) with significant mortality.
- Existing treatments for COVID-19 have shown controversial efficacy, necessitating novel therapeutic strategies.
- Androgen-deprivation therapies (ADT) used for prostate cancer (PCa) have emerged as potentially protective against COVID-19.
Purpose of the Study:
- To investigate the potential protective role of prostate cancer treatments against COVID-19.
- To explore the molecular mechanisms underlying the interaction between SARS-CoV-2 and prostate cancer.
Main Methods:
- Review of existing literature on COVID-19, prostate cancer, and androgen-deprivation therapies.
- Analysis of potential molecular targets and genetic aberrations common to both diseases, including Androgen Receptor (AR) and TMPRSS2.
Main Results:
- Preliminary data suggests a possible protective effect of ADT in COVID-19 patients.
- Potential links identified between SARS-CoV-2 host cell targets and PCa molecular signatures.
- The study highlights the need for further investigation into shared pathways.
Conclusions:
- Prostate cancer treatments, particularly ADT, warrant further investigation as potential therapeutic options for COVID-19.
- Understanding the molecular crosstalk between SARS-CoV-2 and PCa could reveal new treatment avenues.
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