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Clinical study of laminar resorption: Part 1 - Factors affecting laminar resorption
Venkata S Avadhanam1, Jordan V Chervenkoff2, Mehran Zarei-Ghanavati3
1Sussex Eye Hospital, Brighton, UK; Brighton and Sussex Medical School, Brighton, UK; Bristol Eye Hospital, Bristol, UK.
Laminar resorption in osteo-odonto-keratoprosthesis (OOKP) affects nearly 70% of patients, particularly those with poor oral health and Stevens-Johnson syndrome. Resorption typically occurs within the first three years post-surgery.
Area of Science:
- Ophthalmology
- Dental Surgery
- Biomaterials Science
Background:
- Osteo-odonto-keratoprosthesis (OOKP) is a complex procedure for severe corneal blindness.
- Laminar resorption is a known complication affecting the long-term success of OOKP.
- Understanding resorption factors is crucial for improving patient outcomes.
Purpose of the Study:
- To analyze factors influencing laminar resorption in the UK osteo-odonto-keratoprosthesis (OOKP) cohort.
- To provide a detailed review of resorption in OOKP patients.
Main Methods:
- Retrospective review of 64 patients who underwent OOKP between 1996 and 2014.
- Analysis of 74 implanted laminae (tibial grafts, tooth allografts, tooth autografts).
- Correlation of resorption with patient demographics, oral health, and surgical timing.
Main Results:
- 69% of implanted laminae showed resorption.
- Poor oral health, smoking, and dentition quality were associated with resorption.
- Stevens-Johnson syndrome patients had the highest resorption rates (43%).
- Laminar thickness and time between surgeries did not significantly impact resorption.
Conclusions:
- Laminar resorption is common in OOKP, with most cases detected within three years.
- Poor oral health is a significant risk factor.
- Resorption onset after stage 1 did not affect post-stage 2 resorption.
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