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Feedback Inhibition00:46

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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Updated: Dec 13, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Author's reply

Antti Mustonen1, Solja Niemelä2, Tanja Nordström3

  • 1Center for Life Course Health Research, University of Oulu; and Medical Research Center Oulu, Oulu University Hospital, Finland

The British Journal of Psychiatry : the Journal of Mental Science
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No abstract available in PubMed .

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