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Published on: April 28, 2015
Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast
Laura Marcela Forero Ramirez1, Elise Gobin2, Rachida Aid-Launais3
1Laboratory for Vascular Translational Science, UMRS1148, INSERM, Université de Paris, F-75018 Paris, France; Université Sorbonne Paris Nord, F-93430 Villetaneuse, France; Laboratoire Polymères Biopolymères Surfaces, CNRS UMR 6270 & FR3038, Normandie Université, Université de Rouen, INSA de Rouen, F-76821 Mont Saint Aignan, France.
Abstract:
Early detection of thrombotic events remains a big medical challenge. Dextran-based submicronic particles bearing Gd(DOTA) groups and functionalized with fucoidan have been produced via a simple and green water-in-oil emulsification/co-crosslinking process. Their capacity to bind to human activated platelets was evidenced in vitro as well as their cytocompatibility with human endothelial cells. The presence of Gd(DOTA) moieties was confirmed by elemental analysis and total reflection X-ray fluorescence (TRXF) spectrometry. Detailed characterization of particles was performed in terms of size distribution, morphology, and relaxation rates. In particular, longitudinal and transversal proton relaxivities were respectively 1.7 and 5.0 times higher than those of DOTAREM. This study highlights their potential as an MRI diagnostic platform for atherothrombosis.
