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X Ayrignac1, N Gaillard1, C Carra-Dallière1

  • 1Département de Neurologie, CHU Montpellier, Univ Montpellier, Inserm, Montpellier, France.

La Revue De Medecine Interne
|July 29, 2020
PubMed
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Small vessel disease, a common cause of stroke and cognitive decline in aging individuals, is diagnosed via MRI. Therapeutic approaches like blood pressure control and physical activity may help manage its progression.

Area of Science:

  • Neurology
  • Radiology
  • Geriatrics

Background:

  • Small vessel disease is prevalent in aging populations, contributing to approximately 25% of strokes.
  • It is linked to cognitive impairment, dementia, and gait disturbances.
  • Diagnosis relies on Magnetic Resonance Imaging (MRI) findings such as white matter hyperintensities, lacunar infarcts, microbleeds, and enlarged perivascular spaces.

Purpose of the Study:

  • To review the diagnostic features of cerebral microangiopathy.
  • To summarize therapeutic strategies for managing small vessel disease progression.
  • To discuss the prevention of strokes, cognitive decline, and gait impairment associated with small vessel disease.

Main Methods:

  • Comprehensive literature review.
  • Analysis of diagnostic criteria for small vessel disease on MRI.
Keywords:
DiagnosisDiagnosticDiagnostic différentielDifferential diagnosisMicroangiopathie cérébraleSmall vessel disease of the brainTraitementTreatment

Related Experiment Videos

  • Summary of current therapeutic interventions.

    • Main Results:

    • MRI is crucial for diagnosing small vessel disease and differentiating it from other conditions like inflammatory disorders or cerebral amyloid angiopathy.
    • Vascular risk factors, including age and hypertension, are associated with small vessel disease.
    • The efficacy of managing these risk factors remains under investigation.

    Conclusions:

    • Small vessel disease diagnosis is primarily based on characteristic MRI findings.
    • Therapeutic approaches, including blood pressure normalization and physical activity, are discussed for managing the condition.
    • Further research is needed to clarify the benefits of controlling vascular risk factors in preventing stroke and neurological deficits.