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Updated: Dec 13, 2025

An Efficient Sample Preparation Method to Enhance Carbohydrate Ion Signals in Matrix-assisted Laser Desorption/Ionization Mass Spectrometry
Published on: July 29, 2018
Gold and silver nanoparticles-based laser desorption/ionization mass spectrometry method for detection and
Artur Kołodziej1, Tomasz Ruman2, Joanna Nizioł2
1Doctoral School of Engineering and Technical Sciences, Rzeszów University of Technology, 8 Powstańców Warszawy Ave., Rzeszów, 35-959, Poland.
Abstract:
A comparison of ionization efficiency for gold and silver nanoparticles used as an active media of matrix-less laser desorption/ionization (LDI) mass spectrometry (MS) methods was made for carboxylic acids including fatty acids. The matrix-assisted laser desorption/ionization (MALDI)-type targets containing monoisotopic cationic 109 Ag nanoparticles (109 AgNPs) and Au nanoparticles (AuNPs) were used for rapid MS measurements of 10 carboxylic acids of different chemical properties. Carboxylic acids were directly quantified in experiments with 10 000-fold concentration change conditions ranging from 1 mg/ml to 100 ng/ml which equates to 1 μg to 100 pg of carboxylic acids per measurement spot.
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