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Primary breast lymphoma: A single-centre experience.

Mang Yik Foo1, Wai Peng Lee1, Chin Mui Jaime Seah1

  • 1Division of Breast Surgery, Department of General Surgery, Changi General Hospital, Singapore.

Cancer Reports (Hoboken, N.J.)
|July 29, 2020
PubMed
Summary
This summary is machine-generated.

Primary breast lymphoma is rare, often mimicking breast cancer. This study found that non-disseminated primary breast lymphoma shows good survival outcomes with systemic chemotherapy treatment.

Keywords:
Southeast Asiachemotherapyoverall survivalprimary breast lymphoma

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Area of Science:

  • Oncology
  • Hematology
  • Pathology

Background:

  • Primary non-Hodgkin lymphoma of the breast is an extremely rare malignancy, accounting for less than 0.5% of all breast lesions.
  • Clinical data on primary breast lymphoma, particularly from Southeast Asia, is scarce due to its rarity.

Purpose of the Study:

  • To review the clinical presentation, diagnostic methods, treatment strategies, and survival outcomes of patients with primary breast lymphoma.
  • To highlight the importance of accurate histological diagnosis for effective management.

Main Methods:

  • Retrospective analysis of a prospectively collected database of patients diagnosed with primary breast lymphoma between 2011 and 2017.
  • Histological confirmation of lymphoma involving the breast through core, incisional, or excisional biopsies.
  • Review of patient demographics, clinical presentation, disease staging (Ann Arbor classification), treatment regimens (CHOP with rituximab), and survival data.

Main Results:

  • Seven female patients with a median age of 65 presented with unilateral large breast or axillary masses.
  • Common diagnoses included diffuse large B-cell lymphoma (5 patients), marginal zone lymphoma (1), and follicular lymphoma (1).
  • Nondisseminated disease showed a median survival of 57 months, with an overall 3-year survival rate of 64% following chemotherapy.

Conclusions:

  • Primary breast lymphoma, while uncommon, can mimic breast carcinoma clinically.
  • Nonsurgical management with systemic chemotherapy is the primary treatment modality.
  • Accurate histological diagnosis is crucial, and patients with nondisseminated disease demonstrate favorable survival with chemotherapy.