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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

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Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Updated: Dec 13, 2025

Extraction of Plant-based Capsules for Microencapsulation Applications
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Double-Layered Microcapsules Significantly Improve the Long-Term Effectiveness of Essential Oil.

Ting Zhang1, Yu Luo1, Mingxing Wang2

  • 1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, China.

Polymers
|July 30, 2020
PubMed
Summary

This study developed double-layered microcapsules using beta-cyclodextrin, chitosan, and sodium alginate to enhance essential oil effectiveness. These microcapsules offer sustained release and potential applications in various consumer products.

Keywords:
double-layered microcapsulesessential oilsustained release

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Textile Chemistry

Background:

  • Essential oils offer numerous benefits but suffer from poor long-term effectiveness and stability.
  • Developing advanced encapsulation techniques is crucial for preserving and prolonging the release of active compounds from essential oils.

Purpose of the Study:

  • To create and characterize a novel double-layered microcapsule system for improved essential oil delivery.
  • To optimize the preparation process of these microcapsules using the response surface method.
  • To evaluate the application of these microcapsules in functionalizing cotton fabric.

Main Methods:

  • Preparation of double-layered microcapsules using inclusion encapsulation with beta-cyclodextrin (inner layer) and chitosan/sodium alginate (outer layer).
  • Optimization of the preparation process via response surface methodology.
  • Characterization of microcapsule properties: morphology, particle size, encapsulation efficiency, thermal stability, and sustained release.
  • Loading of microcapsules onto cotton fabric using the soak-roll method.

Main Results:

  • Spherical microcapsules with particle sizes ranging from 2-6 μm were successfully prepared.
  • High encapsulation efficiency (up to 80%) and good thermal stability (within 250 °C) were achieved.
  • Sustained release of essential oil active ingredients was demonstrated under both normal and high-temperature conditions.
  • Cotton fabric functionalized with microcapsules exhibited excellent washability, rubbing fastness, and retained fragrance for two months.

Conclusions:

  • The developed double-layered microcapsules effectively enhance the long-term performance of essential oils.
  • The microcapsule system demonstrates significant potential for applications in textiles, offering sustained fragrance release.
  • Potential applications span across sleep aid, antibacterial products, mosquito repellents, and food science.