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One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles

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Silk Protein-Based Materials for Photothermal Therapy: From Morphologies to Multifunctional Applications.

Dan Wu¹, Huijing Zhao¹

¹National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, No. 199 Ren'ai Road, Industrial Park, Suzhou 215123, PR China.

ACS Applied Bio Materials

|February 23, 2026

Summary

Silk proteins offer a low-toxicity, cost-effective approach for noninvasive photothermal therapy (PTT) in cancer treatment. This review explores silk

Keywords:

drug delivery photothermal therapy scaffold silk protein tumor targeting

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Area of Science:

Biomaterials Science
Nanotechnology
Oncology

Background:

Noninvasive photothermal therapy (PTT) is a promising cancer treatment with benefits like low toxicity and high efficiency.
Silk protein, a natural biomaterial, possesses excellent mechanical stability, biocompatibility, and degradability, making it valuable for PTT research.

Purpose of the Study:

To review the physicochemical properties of silk protein for PTT applications.
To explore various silk protein morphologies (hydrogels, scaffolds, films) loaded with photothermal agents.
To discuss innovative applications and future prospects of silk-based PTT materials.

Main Methods:

Literature review summarizing silk protein properties and PTT applications.
Analysis of different silk morphologies used in conjunction with photothermal agents.
Exploration of synergistic therapeutic strategies involving silk-based PTT.

Main Results:

Silk proteins can be fabricated into diverse forms like hydrogels, scaffolds, and films for PTT.
Silk-based PTT platforms demonstrate potential in drug delivery, antimicrobial therapy, and wound healing.
Multimodal synergistic therapeutic platforms utilizing silk-based PTT are under development.

Conclusions:

Silk protein is a versatile biomaterial for developing advanced PTT strategies.
Silk-based PTT offers advantages in targeted cancer therapy and multimodal treatments.
Further research into silk-based PTT materials can overcome current challenges and unlock new therapeutic avenues.