Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.4K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.4K
Positive Regulator Molecules02:39

Positive Regulator Molecules

6.4K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.4K
Positive Regulator Molecules01:45

Positive Regulator Molecules

130.1K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
130.1K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

6.1K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
6.1K
The Cell Cycle Control System01:28

The Cell Cycle Control System

5.0K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.0K
The Cell Cycle Control System02:11

The Cell Cycle Control System

13.6K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perceptions and experiences of patients with stable coronary heart disease participating in shared decision-making: a qualitative study in China.

BMJ open·2026
Same author

Dietary <i>Lonicera japonica</i> supplementation modulates cecal gut microbial composition and metabolomic profiles in weaned piglets.

Frontiers in veterinary science·2026
Same author

Deployment, dispatch, and delivery: a scoping review of drone-delivered AED for out-of-hospital cardiac arrest.

Frontiers in public health·2026
Same author

Protocol for a single-blind, single-centre, parallel-group, non-inferiority randomised controlled trial: comparison of oxygenation stability between different ventilators in mechanically ventilated patients during intrahospital and interhospital transport.

BMJ open·2026
Same author

Provoking or backfiring? A contingent model of how abusive supervision influences learning from failure through fear.

Frontiers in psychology·2026
Same author

Effects of Leaf Nutrients, Non-Structural Carbohydrates, and Microanatomical Structure on Biomass of Three Tree Species Under Drought Stress.

Biology·2026

Related Experiment Video

Updated: Dec 13, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.2K

Cyclin D-CDK4/6 functions in cancer.

Xueliang Gao1, Gustavo W Leone2, Haizhen Wang3

  • 1Department of Cell and Molecular Pharmacology & Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, United States.

Advances in Cancer Research
|July 30, 2020
PubMed
Summary

Cancer cell cycle regulation involves cyclin-dependent kinases (CDKs). Targeting CDK4/6, crucial for cell cycle progression, offers a promising cancer therapy strategy, with CDK6 showing distinct roles.

Keywords:
AbemaciclibCDK4CDK4/6 inhibitorCDK6CyclinCyclin-dependent kinasesPROTACPalbociclibRBRibociclib

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.1K
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.7K

Related Experiment Videos

Last Updated: Dec 13, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

19.2K
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.1K
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • The cell cycle is regulated by cyclin-dependent kinases (CDKs) and cyclins.
  • Dysregulation of cyclin-CDK complexes is a common feature in cancer development.
  • D-type cyclins with CDK4/6 are critical for the G1 to S phase transition by regulating the retinoblastoma protein (RB).

Purpose of the Study:

  • To explore the role of the cyclin D-CDK axis in cancer.
  • To investigate the therapeutic potential of CDK4/6 inhibitors in cancer treatment.
  • To differentiate the specific functions of CDK4 and CDK6 in cancer.

Main Methods:

  • Review of existing pre-clinical and clinical data on cyclin D-CDK pathways in cancer.
  • Analysis of studies involving CDK4/6 dual-inhibitors as single agents or in combination therapies.
  • Examination of research on the distinct roles of CDK4 and CDK6 in cancer biology.

Main Results:

  • The cyclin D-CDK axis is implicated in various cancer hallmarks including proliferation, senescence, migration, apoptosis, and angiogenesis.
  • CDK4/6 inhibitors demonstrate significant efficacy in pre-clinical and clinical cancer settings.
  • CDK6 exhibits unique functions distinct from CDK4 in the context of cancer.

Conclusions:

  • Targeting the cyclin D-CDK4/6 pathway is a viable strategy for cancer therapy.
  • CDK4/6 inhibitors show promise as monotherapies or in combination treatments.
  • Selective depletion of individual CDKs, particularly CDK6, may offer novel therapeutic avenues for cancer patients.