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Photoaging Skin Therapy with PRP and ADSC: A Comparative Study
Luiz Charles-de-Sá1, Natale Gontijo-de-Amorim2, Andrea Sbarbati2
1Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro-CCS-Bloco C, Avenida Carlos Chagas Filho, 373, Ilha do Fundão, Rio de Janeiro, RJ 21941-902, Brazil.
Stem Cells International
|July 30, 2020
Summary
Platelet-rich plasma (PRP) therapy caused fibrosis in photoaged skin, while adipose-derived stem cells (ADSCs) promoted collagen and elastin regeneration, offering a promising anti-aging effect.
Area of Science:
- Regenerative Medicine
- Dermatology
- Tissue Engineering
Background:
- Adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) possess regenerative potential for innovative therapies.
- Photoaged skin presents challenges in regenerative treatments.
Purpose of the Study:
- To histologically characterize the effects of PRP and ADSC therapies on photoaged skin.
- To compare the regenerative outcomes of PRP versus ADSCs in skin aging.
Main Methods:
- Prospective randomized study with 20 healthy individuals exhibiting skin aging.
- Two treatment protocols: PRP and ADSCs, with biopsies taken pre- and post-treatment (4 months).
Main Results:
- PRP treatment induced dermal fibrosis, characterized by increased collagen and linked elastic fibers.
- ADSC therapy promoted neoelastogenesis, increasing tropoelastin and fibrillin, and improved solar elastosis.
- ADSCs led to increased macrophage polarization and matrix proteinases, suggesting dermal remodeling via elastinolysis.
Conclusions:
- PRP therapy resulted in an inflammatory response and increased dermal thickness with a fibrotic appearance.
- ADSC therapy demonstrated significant anti-aging effects on photoaged human skin, highlighting its therapeutic promise.
