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Updated: Feb 7, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
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The Liquid Genioplasty: Different Techniques Compared.

Mario Goisis1, Sheila Veronese2, Patricija Kasilovska3

  • 1De Clinic, C.so di Porta Ticinese 68, 20123, Milan, Italy.

Aesthetic Plastic Surgery
|February 5, 2026
PubMed
Summary
This summary is machine-generated.

Non-surgical genioplasty effectively corrects chin retrusion. Dermgraft showed superior long-term patient satisfaction compared to hyaluronic acid fillers and standard lipofilling.

Keywords:
ChinComplicationsDermgraftFillerHALipofillingLiquid genioplasty

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Area of Science:

  • Facial Plastic Surgery
  • Aesthetic Medicine
  • Regenerative Medicine

Background:

  • Non-surgical genioplasty offers aesthetic improvement for chin retrusion.
  • Concerns exist regarding bone resorption and vascular occlusion with some techniques.
  • This study evaluates outcomes of various non-surgical chin augmentation methods.

Purpose of the Study:

  • To compare the efficacy and patient satisfaction of different non-surgical chin augmentation techniques.
  • To assess the long-term results of hyaluronic acid fillers, lipofilling, and personalized lipofilling (Dermgraft).
  • To evaluate the impact of pre-treatment shock waves on fat grafting outcomes.

Main Methods:

  • Retrospective analysis of 225 patients undergoing non-surgical genioplasty.
  • Comparison of hyaluronic acid (HA) filler, lipofilling, and Dermgraft procedures.
  • Inclusion of shock wave treatment for a subset of lipofilling patients.
  • 12-month follow-up assessing facial angles and patient satisfaction.

Main Results:

  • All treatments improved facial angles.
  • Hyaluronic acid fillers yielded higher satisfaction at 3 months.
  • Dermgraft demonstrated very high patient satisfaction at 1 year.
  • Results maintenance varied significantly between treatment groups.

Conclusions:

  • Liquid genioplasty is a safe and effective method for correcting chin retrusion.
  • Patient satisfaction is high across different non-surgical techniques.
  • Long-term results and satisfaction are dependent on the specific product or procedure used.