Related Experiment Video
Updated: Feb 7, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
Published on: September 16, 2022
The Liquid Genioplasty: Different Techniques Compared
Mario Goisis1, Sheila Veronese2, Patricija Kasilovska3
1De Clinic, C.so di Porta Ticinese 68, 20123, Milan, Italy.
Background:
Non-surgical genioplasty is one of the best choices in cases of chin retrusion, and it represents a solution for the aesthetic amelioration of facial profile. Recent concerns arose about the risk of bone resorption and vascular occlusion. Different procedures and products may lead to different results. This study reports the experience of a single facial plastic surgeon (M.G.) using non-surgical techniques to fill the chin.
Methods:
This retrospective study assesses 225 patients injected from January 2019 through March 2024 in private clinics in Milan (Italy), London (UK), and Dubai (UAE). Forty-five patients were injected with hyaluronic acid (Genefill DX 1x1 ml, BioScience GmbH, Dümmer, Germany), 90 underwent a lipofilling procedure, and 90 underwent a Dermgraft procedure, that is, a personalized lipofilling, modified by the main author. Half of the last 180 patients underwent shock waves before fat harvesting. Patients were followed up for 12 months, and facial angles and satisfaction data were analyzed. Three experts scored the results over time.
Results:
After all the treatments, facial angles were corrected, but the maintenance of the results varied for the different treatments. Notably, at 3 months, the levels of satisfaction were higher for the HA filler treatment, while at 1 year, the levels of satisfaction were very high for the Dermgraft.
Conclusions:
Liquid genioplasty is a safe technique to correct chin retrusion, with good results and high levels of patient satisfaction. The maintenance of the results varies according to the type of product injected.
Level Of Evidence V:
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Related Concept Videos
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Comparative Excretory Systems
Comparing Experimental Results: Student's t-Test
Comparing the Survival Analysis of Two or More Groups
Comparing Intermolecular Forces: Melting Point, Boiling Point, and Miscibility
Temporary attractive forces like dispersion are present in all molecules, whether they are polar or nonpolar. They...
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

