Related Experiment Video

Updated: Dec 13, 2025

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

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Novel Approaches to the Systemic Management of Uveal Melanoma

Shaheer Khan1, Richard D Carvajal2,3

  • 1Department of Hematology and Oncology, Columbia University Irving Medical Center, 177 Ft. Washington Avenue, MHB 6GN-435, New York, NY, 10032, USA. sk4488@cumc.columbia.edu.

Current Oncology Reports
|July 30, 2020
PubMed
Abstract

Insights

Uveal melanoma treatment remains challenging, but novel therapies show promise. This review covers pathophysiology, current systemic options for advanced disease, and future directions for uveal melanoma.

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • Uveal melanoma is a rare eye cancer with unique biology.
  • It shows a distinct response to immune therapies.
  • Advanced disease treatment options are limited.

Purpose of the Study:

  • To review the pathophysiology of uveal melanoma.
  • To discuss current systemic treatment options for advanced uveal melanoma.
  • To explore potential future therapeutic directions.

Main Methods:

  • Literature review of current understanding and research.
  • Analysis of systemic treatment options, including checkpoint blockade.
  • Evaluation of novel agents like tebentafusp and IDE196.

Main Results:

  • Single-agent checkpoint blockade has shown limited efficacy.
  • Combined checkpoint blockade offers modest promise.
  • Novel agents like tebentafusp and IDE196 are under investigation.

Conclusions:

  • Advanced uveal melanoma treatment is challenging.
  • Emerging therapies offer hope for improved outcomes.
  • Continued research into novel agents is crucial.
Keywords:
ImmunotherapyTargeted therapyUveal melanoma

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